N-Acetyl Phytosphingosine Moisturizer Raw Material CAS 21830-28-4 Naps N-Acetylphytosphingosine

• Customization: Available
• CAS No.: 21830-28-4
• Formula: C20h41no4
• Model NO.: LYPH- N-Acetyl Phytosphingosine
• EINECS: N/a
• Color: White
• Appearance: Powder
• Product Name: N-Acetylphytosphingosine
• CAS: 21830-28-4
• Sample: Available
• Other Name: N-Acetyl Phytosphingosine
• Usage: Cosmetic Raw Materials
• MOQ: 10g
• Abbreviation: Naps
• Storage: Store Cool Dry Place
• Mf: C20h41no4
• MW: 359.54
• Boiling Point: 569.3 ± 50.0 °
• Stock: Available
• Solubility: DMSO: Soluble; Ethanol: Soluble
• Density: 1.003±0.06 g/cm3(
• Transport Package: 1kg/Bag or 20/25kg/Drum
• Specification: 99%
• Trademark: Lyphar
• Origin: China
• HS Code: 2924199090
• Production Capacity: 100kg/Month

Product Description

 Moisturizer Raw Material CAS 21830-28-4 NAPS N-acetylphytosphingosine

Product name:	N-acetylphytosphingosine;N-Acetyl Phytosphingosine
Other names:	PHYTOCERAMIDE C2
Grade:	Cosmetic
Cas no:	21830-28-4
MF:

N-acetylphytosphingosine (NAPS) can induce apoptosis in human leukemia Jurkat cell line and increase apoptosis in irradiated MDA-MB-231 cells. We first examined the effect of NAPS on apoptosis of Jurkat cells. N-acetylphytosphingosine (NAPS) had a more rapid and stronger apoptotic effect than C2-ceramide in Jurkat cells and significant increase of apoptosis was observed at 3 h after treatment. In contrast, the apoptosis induced by C2-ceramide was observed only after 16 h of treatment.

N-Acetyl Phytosphingosine induced apoptosis was mediated by caspase 3 and 8 activation and inhibited by z-VAD-fmk. Ceramide plays a pivotal role in radiation induced apoptosis. We postulated that exogenous treatment of NAPS sensitizes tumor cells to ionizing radiation, since NAPS might be used as a more effective alternative to C2-ceramide. As expected, N-acetylphytosphingosine (NAPS)decreased clonogenic survival of irradiated MDA-MB-231 cells dose dependently, and apoptosis of irradiated cells in the presence of NAPS was increased through the caspase activation.

Taken together, N-Acetyl Phytosphingosine is an effective apoptosis-inducing agent, which can be readily synthesized from yeast sources, and is a potent alternative to ceramide for the further study of ceramide associated signaling and the development of radiosensitizing agent.
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1. N-acetyl phytosphingosine is used in cosmetics to support skin barrier function and treat inflammatory skin conditions like acne and eczema. It has anti-inflammatory properties and can reduce inflammation in keratinocytes.
2. N-acetyl phytosphingosine is a phospholipid constituent of the cell membrane that regulates calcium and lipid metabolism, cell proliferation, and differentiation.
3. N-acetyl phytosphingosine can suppress the production of prostaglandin E2 and repress the activity of human cancer cells.